Gallstone disease occurs when hard deposits form in the gallbladder, a small organ beneath the liver. These stones can vary in size and composition and may block the bile ducts, causing intense abdominal pain, nausea, and vomiting, known as a gallbladder attack. Risk factors include obesity, rapid weight loss, a high-fat diet, and certain medical conditions. Treatment options range from medication to dissolve stones, to surgical removal of the gallbladder, called cholecystectomy. Lifestyle changes such as maintaining a healthy weight and diet low in saturated fats can help prevent gallstone formation. Prompt medical attention is crucial for severe symptoms or complications.