Myelofibrosis is a rare bone marrow disorder characterized by the abnormal accumulation of fibrous tissue, leading to the impairment of blood cell production. This condition can cause anemia, weakness, fatigue, and an enlarged spleen. Myelofibrosis may also increase the risk of infections and bleeding. Treatment aims to manage symptoms and complications, often involving medications to improve blood counts, blood transfusions, and in some cases, stem cell transplantation. Myelofibrosis is a chronic condition that requires ongoing medical management and monitoring to optimize quality of life and reduce the risk of complications. Early diagnosis and intervention are crucial for effective management.